Progress has been made in developing manufacturing technologies which enable the fabrication of artificial vascular networks for tissue cultivation. However, those networks are often rudimentary designed with respect to their geometry. This restricts long-term biological functionality of vascular cells which depends on geometry-related fluid mechanical stimuli and the avoidance of vessel occlusion.
Computational fluid dynamics simulations enable bio-inspired geometry optimization for bifurcations in artificial vascular networks. The simulation results enable the derivation of design rules for geometrical parameters such as the branching angle. Those design rules are not only beneficial for tissue engineering applications. Moreover, they can be used as indicators for diagnoses of vascular diseases.